In the speech of March 23, 2001, Luis Colosio Fernández asked, questioning justice in Mexico: "is there no authority from whom to demand justice?"[13]​ In a general context, Colosio's father did not consider that public opinion should be evidence, nor that the vox populi should be the court of conscience; what Colosio's father sought was the congruence of the Public Ministry.[13]​ Luis Colosio Fernández who established himself as the authentic authority, with what he supposes of morality, by denouncing – as his son had done before – the use of laws to commit injustices, and the use of words to turn a deaf ear and hide the truth. According to what he expressed on March 23, 2001, he expected justice "to show that Mexico was not wrong."[13]​[14]​.

From 2000 to 2006 he was a senator for the National List in the first position of his constituency, taking Blanca Ruth Esponda Espinosa as his substitute. Due to his deteriorated health due to kidney disease, he was unable to hold office for most of his term, taking attendance 10 times throughout his term and supporting the roll-call vote on 18 bills.[2]​ He was a member of the agriculture and livestock commission of the Senate of the Republic.[15]​.

As Senator of the Republic, he asked that the proposal that his son Luis Donaldo Colosio receive the Belisario Domínguez medal be withdrawn.[16]​ He also fought for increased protection in the Upper Gulf of California for the marine species Totoaba") and Vaquita Marina while also ensuring that the income of fishermen in the area was not damaged by protectionist measures.[17]​ He was the architect of the proposal to standardize the prices of the gasoline on the northern border of the country with those on the southern border of the United States.[18]​.

He belonged to different civil society organizations in Magdalena de Kino, being a permanent member of the board of the Red Cross and the firefighters. He was an active member of the Rotary Club. He participated in the Surveillance Council of the Regional Livestock Union in Sonora. Likewise, he was regional advisor of Bancomer from 1966 to 1989.[2]​.

He held several presidencies of regional associations, among which the following stand out:[2]​.

He died on February 6, 2010 due to pneumonia in Hermosillo, Sonora.[19] He was buried in the Magdalena de Kino cemetery in the mausoleum of his son and daughter-in-law Diana Laura Riojas, the three of them rest there together.

In the speech of March 23, 2001, Luis Colosio Fernández asked, questioning justice in Mexico: "is there no authority from whom to demand justice?"[13]​ In a general context, Colosio's father did not consider that public opinion should be evidence, nor that the vox populi should be the court of conscience; what Colosio's father sought was the congruence of the Public Ministry.[13]​ Luis Colosio Fernández who established himself as the authentic authority, with what he supposes of morality, by denouncing – as his son had done before – the use of laws to commit injustices, and the use of words to turn a deaf ear and hide the truth. According to what he expressed on March 23, 2001, he expected justice "to show that Mexico was not wrong."[13]​[14]​.

From 2000 to 2006 he was a senator for the National List in the first position of his constituency, taking Blanca Ruth Esponda Espinosa as his substitute. Due to his deteriorated health due to kidney disease, he was unable to hold office for most of his term, taking attendance 10 times throughout his term and supporting the roll-call vote on 18 bills.[2]​ He was a member of the agriculture and livestock commission of the Senate of the Republic.[15]​.

As Senator of the Republic, he asked that the proposal that his son Luis Donaldo Colosio receive the Belisario Domínguez medal be withdrawn.[16]​ He also fought for increased protection in the Upper Gulf of California for the marine species Totoaba") and Vaquita Marina while also ensuring that the income of fishermen in the area was not damaged by protectionist measures.[17]​ He was the architect of the proposal to standardize the prices of the gasoline on the northern border of the country with those on the southern border of the United States.[18]​.

He belonged to different civil society organizations in Magdalena de Kino, being a permanent member of the board of the Red Cross and the firefighters. He was an active member of the Rotary Club. He participated in the Surveillance Council of the Regional Livestock Union in Sonora. Likewise, he was regional advisor of Bancomer from 1966 to 1989.[2]​.

He held several presidencies of regional associations, among which the following stand out:[2]​.

He died on February 6, 2010 due to pneumonia in Hermosillo, Sonora.[19] He was buried in the Magdalena de Kino cemetery in the mausoleum of his son and daughter-in-law Diana Laura Riojas, the three of them rest there together.