In 1851, over four years, he built a 251m railway bridge (also for other vehicles) over the Niagara River in Canada. During this period he undertook the construction of a second bridge in Kentucky, which was suspended due to financial problems and was later completed with a metal lattice. The Pittsburgh Suspension Bridge, 314 m in total length, was completed in 1859.

The American Civil War brought a temporary cessation of Roebling's activity. However, in 1863 construction resumed on a bridge over the Ohio River at Cincinnati, which had begun in 1856 and which was stopped due to lack of funding; the bridge was completed in 1867. The Cincinnati-Covington Bridge, later known as the John A. Roebling Suspension Bridge, was the longest suspension bridge in the world at the time it was completed, spanning 322 m.

In 1867 Roebling began the design of the Brooklyn Bridge (with a span of 486.3 m), which crosses the East River in New York. One day in 1869, when he was on the edge of a dock working on fixing the location where the bridge would be built, his foot was crushed by a docking ferry. His injured toes were amputated. He refused medical treatment, pretending to cure his foot through "water therapy" (continuously pouring water on the wound). His condition deteriorated irreversibly, and he succumbed to a tetanus infection 24 days after the accident.[7] Roebling is buried at Riverview Cemetery in Trenton, New Jersey.

His son, Washington Roebling continued the work until its completion in 1883; In turn, he was incapacitated in 1872 due to decompression syndrome, and finally his wife, Emily Warren Roebling, was in charge of the effective direction of the construction of the bridge.

Starting in 1844, he won several contracts for the construction of hanging structures (a bridge and an aqueduct in Pittsburgh, and four other aqueducts in Delaware), and moved his wire factory to Trenton (New Jersey), transforming it into a large industrial facility.

In 1851, over four years, he built a 251m railway bridge (also for other vehicles) over the Niagara River in Canada. During this period he undertook the construction of a second bridge in Kentucky, which was suspended due to financial problems and was later completed with a metal lattice. The Pittsburgh Suspension Bridge, 314 m in total length, was completed in 1859.

The American Civil War brought a temporary cessation of Roebling's activity. However, in 1863 construction resumed on a bridge over the Ohio River at Cincinnati, which had begun in 1856 and which was stopped due to lack of funding; the bridge was completed in 1867. The Cincinnati-Covington Bridge, later known as the John A. Roebling Suspension Bridge, was the longest suspension bridge in the world at the time it was completed, spanning 322 m.

In 1867 Roebling began the design of the Brooklyn Bridge (with a span of 486.3 m), which crosses the East River in New York. One day in 1869, when he was on the edge of a dock working on fixing the location where the bridge would be built, his foot was crushed by a docking ferry. His injured toes were amputated. He refused medical treatment, pretending to cure his foot through "water therapy" (continuously pouring water on the wound). His condition deteriorated irreversibly, and he succumbed to a tetanus infection 24 days after the accident.[7] Roebling is buried at Riverview Cemetery in Trenton, New Jersey.

His son, Washington Roebling continued the work until its completion in 1883; In turn, he was incapacitated in 1872 due to decompression syndrome, and finally his wife, Emily Warren Roebling, was in charge of the effective direction of the construction of the bridge.